Individual variations in arsenic metabolism in Vietnamese: the association with arsenic exposure and GSTP1 genetic polymorphism

Some new substituted benzaldehyde (2,3,4,6-tetra-O-acetyl-a-D-galactopyranosyl) thiosemicarbazones were synthesised by reaction of 2,3,4,6-tetra-O-acetyl-a-D-galactopyranosyl thiosemicarbazide and different substituted benzaldehydes. The reaction was performed using conventional and microwave-assisted heating methods. The structures of thiosemicarbazones were confirmed by spectroscopic (IR, H-1 NMR, C-13 NMR and MS) method. The antioxidant activity of these thiosemicarbazones was evaluated, in vitro and in vivo, and it's shown that some of these compounds had significant antioxidant activity.

Title: 

Individual variations in arsenic metabolism in Vietnamese: the association with arsenic exposure and GSTP1 genetic polymorphism
Authors: Nguyen, Minh Tue
Vi, Thi Mai Lan
Pham, Thi Kim Trang
Pham, Hung Viet
Tetsuro Agusa
Keywords: Antioxidant activity
D-galactose
microwave-assisted
thiosemicarbazones
thiosemicarbazones
Issue Date: 2012
Publisher: MEDKNOW PUBLICATIONS & MEDIA PVT LTD, B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075, INDIA
Citation: ISIKNOWLEDGE
Abstract: Some new substituted benzaldehyde (2,3,4,6-tetra-O-acetyl-a-D-galactopyranosyl) thiosemicarbazones were synthesised by reaction of 2,3,4,6-tetra-O-acetyl-a-D-galactopyranosyl thiosemicarbazide and different substituted benzaldehydes. The reaction was performed using conventional and microwave-assisted heating methods. The structures of thiosemicarbazones were confirmed by spectroscopic (IR, H-1 NMR, C-13 NMR and MS) method. The antioxidant activity of these thiosemicarbazones was evaluated, in vitro and in vivo, and it's shown that some of these compounds had significant antioxidant activity.
Description: TNS07065 ; METALLOMICS Volume: 4 Issue: 1 Pages: 91-100 Published: 2012
URI: http://repository.vnu.edu.vn/handle/VNU_123/29639
ISSN: 0250-474X
Appears in Collections:Bài báo của ĐHQGHN trong Web of Science

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